Not Medical Advice: No. Piegler's Oakworm (Anisota peigleri), though an occasional pest on oak trees in the southeastern United States, is not yet specifically known to be poisonous.
Anisota peigleri occurs in southeastern Kentucky, eastern Tennessee, western North Carolina, the Piedmont and coastal areas of South Carolina, northern Georgia, Alabama and north central Florida. Gainesville, Florida is the southern-most point at which it has been collected. The biologically similar orangestriped oakworm, Anisota senatoria (J. E. Smith), has a much larger range, occurring from Minnesota and Maine southward to Texas and Florida (Tuskes et al. 1996, Riotte & Peigler 1980, Serrano & Foltz 2003).
The adult female is reddish-orange in color and about 3/4 to 1 inch (18 to 25 mm) in length. The forewing has a small white spot, a dark line, and numerous dark speckles. The hind wings are somewhat paler and have an indistinct line.
Females are distinguished from males by their larger size, threadlike antennae, and the characteristic shape and coloration of the wings. Males are smaller than females, the body ranging from 5/8 to 3/4 of an inch (15 - 20 mm) in length.
The forewings are dark reddish brown with a small white spot and a larger whitish translucent patch. The hindwings are mostly reddish brown. Males have plumose (featherlike) antennae that they use to locate females by tracking the pheromones females release during their "calling."
Know more about Yellowstriped Oakworm (Peigler's oakworm) at edis.ifas.ufl.edu.