No, Clint Eastwood and John Wayne never starred in a film together.
Clint Eastwood wanted to work with John Wayne in a western, but the feeling wasn't mutual.
"I gave him a piece of material that I thought had potential for us to do as a younger guy and an older guy. He wrote me back critical of it. He had seen High Plains Drifter, and he didn't think that represented Americana like She Wore a Yellow Ribbon and other John Ford westerns. I never answered him".
View Clint Eastwood and John Wayne filmographies on IMDb.
Eastwood and Wayne are legends of Western films. Which one of these two Western legends is your favorite? Discuss the list at IMDb.