No. Neil Patrick Harris did not appear in the 2001 movie Scary Movie 2. See full cast of the movie on IMDb.
Actor Neil Patrick Harris has starred in TV sitcoms Doogie Howser, M.D. and How I Met Your Mother. He has also performed on stage in productions like Rent, Cabaret and Hedwig and the Angry Inch.
Born June 15, 1973, Neil Patrick Harris was 15 when he starred opposite Whoopi Goldberg in Clara's Heart. The next year, he began four seasons playing the title role in the TV sitcom Doogie Howser, M.D. Harris then appeared in films and TV movies, as well as on stage, in Rent and Cabaret. In 2005, he landed the role of Barney Stinson on How I Met Your Mother. Harris is openly gąy and the father of twins.
Tip! View Neil Patrick Harris filmography on IMDb.