No, Jesse Metcalfe and Laurie Metcalf are not related. Their names are spelled differently as well.
Laurie Metcalf was born on June 16, 1955, in Carbondale, Illinois, and grew up in nearby Edwardsville. She became an original ensemble member of the Steppenwolf Theatre Company in the 1970s.
After generating buzz as a stage actress, she earned widespread attention through her Emmy-winning role of Jackie on the popular 1990s sitcom Roseanne. Metcalf joined the all-star cast for the animated hit Toy Story (1995) and its sequels, and drew praise for her work in TV programs like The Big Bang Theory and Getting On. She has also remained heavily involved in the theater, earning Tony Award consideration for her performances in November and Misery.
Jesse Eden Metcalfe on the other hand was born in Carmel Valley, California, to Nancy (DeMaio) and Jeff Metcalfe. He has Italian, Portuguese, English, French, and Irish ancestry. He was raised in Southeastern Connecticut.
Metcalfe first appeared on the small screen in NBC's daytime drama, 'Passions', but rose to fame on the mega-hit series, 'Desperate Housewives' playing teenage boy-toy, John Rowland. He's since been the lead in both studio and independent features. Best known for carrying Twentieth Century Fox's successful teen-comedy "John Tucker Must Die" and starring opposite Michael Douglas in "Beyond A Reasonable Doubt".
Here are some celebrity pairs who have the same last name but aren't actually related shared by J-14.com.