No. A lot have thought that its a Talking Heads song, but Send Me On My Way is a Rusted Root original - appearing in the soundtracks of both Matilda and Ice Age, on the TV show Chuck and New Girl, and in the commercials for Enterprise Rent-A-Car.
Rusted Root had seven members at the time, and they all shared the songwriting credit on this one. Their frontman Michael Glabicki wrote the lyrics, and their other members - Liz Berlin, John Buynak, Jim Dispirito, Jim Donovan, Patrick Norman and Jennifer Wertz - contributed to the track.
There are some phrases in this song that if you believe hard enough can form real words, but are really just made up.
An influence on this song was Toni Childs, an American singer who uses many African sounds in her work. Like Rusted Root, she had just one Hot 100 entry ("Don't Walk Away," 1988) and it also placed at #72.
Learn more facts about this track on SongFacts.com.