Not Medical Advice: Yes, as there is no known negative interaction found for taking Zofran and Suboxone at the same time.
See drugs that are known to interact with Zofran (ondansetron) and drugs that are known to interact with Suboxone (buprenorphine / naloxone) at Drugs.com..
Zofran (ondansetron) blocks the actions of chemicals in the body that can trigger nausea and vomiting.
Zofran is used to prevent nausea and vomiting that may be caused by surgery or by medicine to treat cancer (chemotherapy or radiation). It is not for preventing nausea or vomiting that is caused by factors other than cancer treatment or surgery.
Suboxone contains a combination of buprenorphine and naloxone. Buprenorphine is an opioid medication. An opioid is sometimes called a narcotic. Naloxone blocks the effects of opioid medication, including pain relief or feelings of well-being that can lead to opioid abuse.
Suboxone is used to treat narcotic (opiate) addiction. It is not for use as a pain medication.
Tip! Find out what you can do to make sure you get the most benefit from the medication and stay safe in the proces at WebMD..